Resource library

Objective: We sought to develop a weak supervision-based approach to demonstrate feasibility of post-market surveillance of wearable devices that render AF pre-diagnosis. Materials and Methods: Two approaches were evaluated to reduce clinical note labeling overhead for creating a training set for a classifier: one using programmatic codes, and the other using prompts to large language models (LLMs). Probabilistically labeled notes…

Zero-shot inference is a powerful paradigm that enables the use of large pretrained models for downstream classification tasks without further training. However, these models are vulnerable to inherited biases that can impact their performance. The traditional solution is fine-tuning, but this undermines the key advantage of pretrained models, which is their ability to be used out-of-the-box. We propose ROBOSHOT, a…

Modern artificial intelligence (AI) systems are powered by foundation models. This paper presents a new set of foundation models, called Llama 3. It is a herd of language models that natively support multilinguality, coding, reasoning, and tool usage. Our largest model is a dense Transformer with 405B parameters and a context window of up to 128K tokens. This paper presents…

Large pretrained models can be used as annotators, helping replace or augment crowdworkers and enabling distilling generalist models into smaller specialist models. Unfortunately, this comes at a cost: employing top-of-the-line models often requires paying thousands of dollars for API calls, while the resulting datasets are static and challenging to audit. To address these challenges, we propose a simple alternative: rather…

As a proof-of-concept, we convened an interactive “red teaming” workshop in which medical and technical professionals stress-tested popular large language models (LLMs) through publicly available user interfaces on clinically relevant scenarios. Results demonstrate a significant proportion of inappropriate responses across GPT-3.5, GPT-4.0, and GPT-4.0 with Internet (25.7%, 16.2%, and 17.5%, respectively) and illustrate the valuable role that non-technical clinicians can…

The third Machine Learning for Health (ML4H) symposium was held in person on December 10, 2023, in New Orleans, Louisiana, USA (Parziale et al., 2022). The symposium included research roundtable sessions to foster discussions between participants and senior researchers on timely and relevant topics for the ML4H community.

Machine learning models that embed graphs in non-Euclidean spaces have shown substantial benefits in a variety of contexts, but their application has not been studied extensively in the biological domain, particularly with respect to biological pathway graphs. Such graphs exhibit a variety of complex network structures, presenting challenges to existing embedding approaches. Learning high-quality embeddings for biological pathway graphs is…

While Transformers underpin modern large language models (LMs), there is a growing list of alternative architectures with new capabilities, promises, and tradeoffs. This makes choosing the right LM architecture challenging. Recently-proposed hybrid architectures seek a best-of-all-worlds approach that reaps the benefits of all architectures. Hybrid design is difficult for two reasons: it requires manual expert-driven search, and new hybrids must…

Detoxifying multilingual Large Language Models (LLMs) has become crucial due to their increasing global use. In this work, we explore zero-shot cross-lingual generalization of preference tuning in detoxifying LLMs. In contrast to prior work that suggests limited crosslingual generalization for other safety tasks, we show that Direct Preference Optimization (DPO) training with only English data can significantly reduce toxicity in…